Endocrine Abstracts

Aim: We aimed to undertake a population-based approach to describing the prevalence and incidence of chronic hypoparathyroidism. There are very few reports on the epidemiology of this condition.Methods: Data linkage of all biochemistry, hospital admissions, prescribing and death records was undertaken in Tayside Scotland (population 400,000) from 1988 to 2015. Patients with at least 3 serum calcium concentrations below the reference range f...

Aim: We aimed to investigate mortality and morbidity in patients who were identified with primary hypoparathyroidism, post-surgical and non-surgical hypoparathyroidism.Methods: The patients who were previously identified with hypoparathyroidism, were linked to hospital admission dataset, renal registry, biochemistry dataset and prescribing dataset. In this study, death and 6 morbidities; cataract, circulatory system, infection, fracture, me...

Aim: We aimed to undertake a population-based approach to describing the prevalence and incidence of chronic hypoparathyroidism. There are very few reports on the epidemiology of this condition.Methods: Data linkage of all biochemistry, hospital admissions, prescribing and death records was undertaken in Tayside Scotland (population 400,000) from 1988 to 2015. Patients with at least 3 serum calcium concentrations below the reference range f...

Aim: We aimed to investigate mortality and morbidity in patients who were identified with primary hypoparathyroidism, post-surgical and non-surgical hypoparathyroidism.Methods: The patients who were previously identified with hypoparathyroidism, were linked to hospital admission dataset, renal registry, biochemistry dataset and prescribing dataset. In this study, death and 6 morbidities; cataract, circulatory system, infection, fracture, me...

A large population-based cohort of “diagnosed” primary hyperparathyroidism (PHPT) (n=2709) was established, 1997–2006, in Tayside, Scotland. We have previously reported on an increasing prevalence and increased risks of mortality and morbidity associated with these patients. In the course of the PEARS, a group of “possible” PHPT cases (n=2950) defined as having persistently elevated serum calcium over several months to years but with no P...

Context: Rising evidence of the increased risk in mild PHPT suggests that serum calcium, which has been a main surgical criterion, maybe not an accurate indicator of disease severity or at least, not a reliable predictive factor of its long-term consequences. This study aims to identify the best biochemical predictor of adverse outcomes in untreated PHPT.Outcome measures and methods: Primary outcomes considered were all-cause mortality, fatal and non-fat...

Clinical Endocrinology 2013 79 27–34. DOI: 10.1111/cen.12206...

Objective: To investigate the management of thyroid replacement during pregnancy in women who were prescribed thyroxine prior to pregnancy.Design: Record-linkage technology was used retrospectively to identify pregnant women who were prescribed thyroxine in the general population of Tayside, Scotland.Patients: All pregnant women who were 18 years and above and who delivered between 1st January 1993 and 31st March 2011 in Tayside we...

The prevalence of primary hyperparathyroidism (PHPT) is increasing and the majority (over 85%) are now asymptomatic and remain untreated. In order to know whether or not they can be left safely without surgery, issues on disease progression need to be addressed. We aimed to update the natural history of PHPT, with a focus of serum calcium progression in mild untreated patients, selected from a large pre-defined cohort of PHPT in Tayside, Scotland. Possible predictors of progre...

Objective: To investigate the long term outcomes for patients with endogenous subclinical hyperthyroidism (SH).Design: Population record-linkage technology was used retrospectively to identify patients with SH and hospital admissions from January 1, 1993 to December 31, 2009.Patients: All residents over 18 years old with at least two serum TSH measurements below the reference range for at least 4 months apart and normal free T...